Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment: A systematic review of current evidence
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- 作者：E.J.M. Schrijver ej.schrijver@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; K. de Graaf k.degraaf@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; O.J. de Vries oj.devries@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; A.B. Maier a.maier@vumc.nl" class="auth_mail" title="E-mail the corresponding author ; P.W.B. Nanayakkara ; p.nanayakkara@vumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Delirium ; Haloperidol ; Prophylaxis ; Treatment ; Elderly ; Systematic review
- 刊名：European Journal of Internal Medicine
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：14-23
- 全文大小：383 K
文摘
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Haloperidol prophylaxis may reduce postoperative delirium in selected populations.
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There are no placebo-controlled trials with haloperidol for delirium treatment.
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RCTs with haloperidol for hospital delirium management show wide variety in design.
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Haloperidol use is not associated with a significant increase in side-effects.
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Trials examining the effects on clinical endpoints such as mortality are lacking.