Testing of a palatable bait and compatible vaccine carrier for the oral vaccination of European badgers (Meles meles) against tuberculosis

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• 作者：Sonya Gowtage^a ; ^{Sonya.Gowtage@apha.gsi.gov.uk} ; Gareth A. Williams^a ; ^{Gareth.a.Williams@apha.gsi.gov.uk} ; Ray Henderson^b ; ^{Pest-Tech@hotmail.com} ; Paul Aylett^c ; ^{paul@connovation.co.nz} ; Duncan MacMorran^c ; ^{duncan@connovation.co.nz} ; Si Palmer^a ; ^{Si.Palmer@apha.gsi.gov.uk} ; Andy Robertson^d ; ^e ; ^{Andy.Robertson@apha.gsi.gov.uk} ; Sandrine Lesellier^a ; ^{Sandrine.Lesellier@apha.gsi.gov.uk} ; Stephen P. Carter^d ; ¹ ; ^{Steve.Carter@apha.gsi.gov.uk} ; ^{stevecarter@vwt.org} ; Mark A. Chambers^a ; ^f ; ^{Mark.Chambers@apha.gsi.gov.uk}
• 关键词：HPO ; hydrogenated (hardened) peanut oil ; QC ; quality control ; PT ; paste-bait ; EP ; European pharmacopoeia ; USP ; United States pharmacopoeia ; IPA ; iophenoxic acid ; TAMC ; total aerobic microbial count ; TYMC ; total yeast and mould count
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：987-992
• 全文大小：945 K
• 卷排序：35

文摘

First report of a physically stable bait for the delivery of BCG to wild badgers. BCG is stable within bait during storage and under simulated deployment conditions. Bait used to deliver oral biomarker to badgers to simulate oral delivery of vaccine. A highly palatable bait combined with a BCG-compatible vaccine carrier. Discussion of requirements for the components of a successful oral wildlife vaccine.