The absence of 25-hydroxyvitamin D3-1α-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light
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- 作者：Yanping Wang ; Steve J. Marling ; Victoria M. Martino ; Jean M. Prahl ; Hector F. Deluca ; deluca@biochem.wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MS ; multiple sclerosis ; CNS ; central nervous system ; BBUVB ; broad band ultraviolet B ; NBUVB ; narrow band ultraviolet B ; EAE ; experimental autoimmune encephalomyelitis ; CYP27B1 ; cytochrome p450 27B1 ; WT ; wild type ; KO ; knock out
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：98-102
- 全文大小：886 K
文摘
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UV light completely blocks EAE in CYP27B1 KO mice.
UV light suppresses expression of cytokines IFN-γ, IL-10 and CCL-5 in spinal cord in EAE susceptible mice.
1,25-OH-D3 reduces effectiveness of UV light in suppressing EAE.