The electrocatalytic cascade assembling of isatins, malononitrile and N

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• 作者：Michail N. Elinson ; Alexey I. Ilovaisky ; Valentina M. Merkulova ; Dmitry V. Demchuk ; Pavel A. Belyakov ; Yuri N. Ogibin ; Gennady I. Nikishin
• 关键词：Electrolysis ; Electrocatalysis ; Spiroheterocycles ; Multicomponent reactions ; Cyclization ; Spiro[indole-3 ; 5′ ; -pyrano[2 ; 3-d]pyrimidines]
• 刊名：Electrochimica Acta
• 出版年：2008
• 出版时间：30 November 2008
• 年：2008
• 卷：53
• 期：28
• 页码：8346-8350
• 全文大小：348 K

文摘

Electrochemically induced catalytic multicomponent transformation of isatins, barbituric acid or N-alkyl barbiturates and malononitrile in alcohols in an undivided cell results in the formation of substituted 7′-amino-2,2′,4′-trioxo-1,1′,2,2′,3′,4′-hexahydrospiro[indole-3,5′-pyrano[2,3-d]pyrimidine]-6′-carbonitriles in 80–95 % yields. The developed efficient electrocatalytic approach to corresponding spiro[indole-3,5′-pyrano[2,3-d]pyrimidine] system is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a new example of the ecologically pure synthetic concept for electrocatalytic multicomponent reactions strategy.