Isolated myelosarcoma development in an adolescent chronic myeloid leukemia patient with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36)

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• 作者：Hale Ö ; ren ; Ş ; ebnem Yı ; lmaz ; Zeynep Sercan ; Fatih Demircioğ ; lu ; Erdinç ; Yü ; ksel ; Gü ; lersu İ ; rken
• 关键词：Modeling hydrogen generator ; Hydrogen predictive models ; Neural network prediction ; Adaptive neuro-fuzzy inference systems ; Hydrogen safety prediction
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2008
• 出版时间：1 April 2008
• 年：2008
• 卷：182
• 期：1
• 页码：43-45
• 全文大小：99 K

文摘

Additional chromosomal abnormalities are found in 5–20 % of patients during chronic phase of chronic myeloid leukemia and in 60–80 % preceding or accompanying blast crisis. These abnormalities are important in disease progression and, because they may occur before hematological and clinical symptoms, can be taken as a prognostic indicator. An adolescent with chronic myeloid leukemia initially presented with extreme thrombocytosis, increased megakaryopoiesis with dysmorphic features, and focal myelofibrosis in bone marrow examinations and then developed isolated myelosarcoma 1 year after onset, with t(9;22)(q34;q11.2), +8, +14, +21, and der(1)(p36).