Elevation in liver enzymes is associated with increased IL-2 and predicts severe outcomes in clinically apparent dengue virus infection
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- 作者：Thamarasi Senaratnea ; Jillian Carrb ; Faseeha Noordeena ; faseehan@pdn.ac.lk" class="auth_mail" title="E-mail the corresponding author ; faseeha.noordeen12@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DENV ; dengue virus ; DF ; dengue fever ; DHF ; dengue haemorrhagic fever ; PCV ; packed cell volume ; DSS ; dengue shock syndrome ; WBC ; white blood cell count ; SEM ; standard error of mean ; CP ; Central Province ; AST ; aspartate aminotransferase ; ALT ; alanine aminotransferase
- 刊名：Cytokine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：182-188
- 全文大小：740 K
文摘
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A significant positive linear correlation was noted between AST & ALT and IL-2 elevations in severe dengue.
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AST and ALT levels correlate with disease severity and circulating IL-2 levels.
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We suggest a role for circulating IL-2 in liver dysfunction mediated by severe dengue and propose that a combined assessment of AST/ALT in conjunction with IL-2 at the early stages of dengue may be useful to predict severe dengue.