Calcitonin gene-related peptide does not interact with sympathetic activity in myocardial ischemia

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• 作者：Burgdorf ; Christof ; Dendorfer ; Andreas ; Kurz ; Thomas ; Richardt ; Gert
• 关键词：Sensory C-fibers ; Norepinephrine release ; Isolated rat heart
• 刊名：Regulatory Peptides
• 出版年：2005
• 出版时间：February 15, 2005
• 年：2005
• 卷：125
• 期：1-3
• 页码：99-102
• 全文大小：156 K

文摘

The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium. In isolated rat hearts subjected to 30 min of low flow ischemia, CGRP release increased 2.8-fold whereas stimulation-induced norepinephrine release decreased 4.1-fold. Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected. At normal flow, exogenous CGRP (5 ??mol l^???1) had no effect on norepinephrine release. These findings suggest that CGRP release from sensory neurons does not interact with the cardiac sympathetic system during myocardial ischemia.