- 作者：Samer George Hakim ; M.D. ; D.M.D. ; Ph.D.&lowast ; ; samer.hakim@mkg-chir.mu-luebeck.de ; Gè ; za Attila Benedek ; M.D. ; D.M.D.&lowast ; ; Yu-xiong Su ; M.D. ; D.D.S. ; Ph.D.&lowast ; ; &dagger ; ; Hans Christian Jacobsen ; M.D. ; D.M.D.&lowast ; ; Matthias Klinger ; M.D. ; Ph.D.&Dagger ; ; Andreas Dendorfer ; M.D. ; Ph.D.§ ; ; Claudia Hemmelmann ; Ph.D.?/sup> ; Birgit Meller ; Ph.D.¶ ; ; Roger Nadrowitz ; Ph.D.# ; Dirk Rades ; M.D. ; Ph.D.# ; Peter Sieg ; M.D. ; D.M.D. ; Ph.D.&lowast ;
- 关键词：Lidocaine ; Radioprotection ; Salivary glands ; Sialoscintigraphy ; Xerostomia
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 出版时间：15 March, 2012
- 年：2012
- 卷：82
- 期：4
- 页码：e623-e630
- 全文大小：1036 K
Purpose
Radiation-induced xerostomia still represents a common side effect after radiotherapy for head-and-neck malignancies. The aim of the present study was to examine the radioprotective effect of lidocaine hydrochloride during fractionated radiation in an experimental animal model.Methods and Materials
To evaluate the influence of different radiation doses on salivary gland function and the radioprotective effect of lidocaine, rabbits were irradiated with 15, 25, 30, and 35 Gy (equivalent doses in 2-Gy fractions equivalent to 24, 40, 48, and 56 Gy, respectively). Lidocaine hydrochloride (10 and 12 mg/kg) was administered before every radiation fraction in the treatment groups. Salivary gland function was assessed by flow sialometry and sialoscintigraphy, and the morphologic changes were evaluated using transmission electron microscopy.
Results
Functional impairment was first observed after 35 Gy and pretreatment with lidocaine improved radiation tolerance of both parotid and submandibular glands. The use of 12 mg/kg lidocaine was superior and displayed significant radioprotection with regard to flow sialometry and sialoscintigraphy. The ultrastructure was largely preserved after pretreatment with both lidocaine doses.
Conclusions
Lidocaine represents an effective radioprotective agent and a promising approach for clinical application to avoid radiation-induced functional impairment of salivary glands.