Absence of CD4+ T cell help generates corrupt CD8+ effector T cells in sarcoma-bearing Swiss mice treated with NLGP vaccine
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- 作者：Sarbari Ghosha ; Madhurima Sarkara ; Tithi Ghosha ; Ipsita Guhaa ; Avishek Bhuniyaa ; Jaydip Biswasb ; Atanu Mallicka ; Anamika Bosea ; 1 ; Rathindranath Barala ; 1 ; baralrathin@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; rathindranath.baral@cnci.org.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：NLGP ; neem leaf glycoprotein ; TCR ; T-cell receptor ; TDLN ; tumor draining lymph node ; KLRG1 ; killer cell lectin-like receptor subfamily G member 1 ; DCs ; dendritic cells ; CTL ; cytotoxic T lymphocytes ; IDO ; indoleamine 2 ; 3-dioxygenase ; APC ; antigen presenting cell ; CD4 Dep ; CD4+ T cell depletion
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：175
- 期：Complete
- 页码：31-39
- 全文大小：2251 K
文摘
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NLGP mediated therapeutic tumor growth restriction is CD8+ T cell dependent.
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In this CD8 dependent tumor growth restriction participation of CD4+ T cells is essential.
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CD4+ T cell depletion increases CD8+ T cell frequency in tumor bearing mice, however, CD8+ T cell functions are seriously hampered.
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CD4+ T cell depletion affects NLGP vaccine induced CD8α+ dendritic cell dependent signaling.
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IL-2 and physical presence of CD4+ T cells are mutually required for optimum CD8+ T cell functions.