The TIP60 Complex Is a Conserved Coactivator of HIF1A
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- 作者：Joel I. Perez-Perri4 ; 6 ; 7 ; Veronica L. Dengler3 ; 6 ; K. Audrey Audetat3 ; Ahwan Pandey2 ; 3 ; Elizabeth A. Bonner2 ; Marjeta Urh5 ; Jacqui Mendez5 ; Danette L. Daniels5 ; Pablo Wappner4 ; Matthew D. Galbraith2 ; 3 ; matthew.galbraith@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author ; Joaquí ; n M. Espinosa1 ; 2 ; 3 ; joaquin.espinosa@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：37-47
- 全文大小：1676 K
文摘
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TIP60 is required for expression of HIF1-dependent genes in Drosophila
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The role of TIP60 at HIF1-dependent genes is conserved in human colorectal cancer cells
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HIF1A interacts with and recruits TIP60 to chromatin
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Many HIF1A targets require TIP60, CDK8, or both for full expression in hypoxia