Potential role of platelet FcγRIIA in collagen-mediated platelet activation associated with atherothrombosis

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• 作者：Calverley ; David C. ; Brass ; Elizabeth ; Hacker ; Michele R. ; Tsao-Wei ; Denice D. ; Espina ; Byron M. ; et. al.
• 关键词：Blood platelets ; Diabetes mellitus ; Cardiovascular disease ; Collagen ; Platelet activation ; Receptors ; Fc
• 刊名：Atherosclerosis
• 出版年：2002
• 出版时间：October, 2002
• 年：2002
• 卷：164
• 期：2
• 页码：261-267
• 全文大小：192 K

文摘

Collagen-mediated platelet activation contributes significantly to coronary and cerebrovascular thrombus formation associated with atherosclerotic plaque destabilization. Recent clinical and laboratory observations support a potential role for the platelet Fc receptor (FcγRIIA) in this process. The purpose of this study was to elucidate any association between platelet Fc receptor (FcR) expression levels and both atherosclerosis risk factors (ARFs) along with collagen-dependent platelet activation. Age and gender-independent variation has been described in the expression of this receptor that is stable over time. Platelet Fc surface expression was compared between patients experiencing an acute coronary or cerebrovascular event, healthy patients with two or more ARFs, and healthy patients with fewer than two ARFs. Platelet FcR expression was significantly and stably (6–52 weeks, mean 20 weeks) increased in 101 patients with acute myocardial infarction, unstable angina, or ischemic stroke syndrome (P<0.001) and 38 healthy patients with two or more ARFs (P