Cathelicidin LL-37 bloodstream surveillance is down regulated during septic shock

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• 作者：Denise Frediani Barbeiro ; Hermes Vieira Barbeiro ; Fernando Godinho Zampieri ; Marcel Cerqueira Cé ; sar Machado ; Francisco Torggler Filho ; Dé ; bora Maria Gomes Cunha ; Alessandra Carvalho Goulart ; Irineu Tadeu Velasco ; Luiz Monteiro da Cruz Neto ; Heraldo Possolo de Souza ; Fabiano Pinheiro da Silvap> ; p>p>pinheirofabiano@hotmail.comp>
• 关键词：Cathelicidin ; Sepsis ; Vitamin D ; Inflammation
• 刊名：Microbes and Infection
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：15
• 期：5
• 页码：342-346
• 全文大小：213 K

文摘

Host defense peptides are ancient weapons of the innate immunity. The human cathelicidin LL-37 protects the epithelial barrier against infection and is constitutively secreted in the bloodstream by immune cells. Current knowledge claims that LL-37 is up regulated upon infection. LL-37 can protect against bacterial infections and possesses many immunomodulatory properties. Here, we show that the human host defense peptide LL-37 is down regulated during septic shock. Furthermore, we show that these effects are not related to vitamin D serum levels, a potent inducer of LL-37 gene expression, pointing out the complex regulation of cathelicidins during septic shock.