Phylogeographic Analysis of Mitochondrial DNA in Northern Asian Populations
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- 作者：Miroslava Derenko ; Boris Malyarchuk ; Tomasz Grzybowski ; Galina Denisova ; Irina Dambueva ; Maria Perkova ; Choduraa Dorzhu ; Faina Luzina ; Hong Kyu Lee ; Tomas Vanecek ; Richard Villems ; Ilia Zakharov
- 刊名：The American Journal of Human Genetics
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：81
- 期：5
- 页码：1025-1041
- 全文大小：7619 K
文摘
To elucidate the human colonization process of northern Asia and human dispersals to the Americas, a diverse subset of 71 mitochondrial DNA (mtDNA) lineages was chosen for complete genome sequencing from the collection of 1,432 control-region sequences sampled from 18 autochthonous populations of northern, central, eastern, and southwestern Asia. On the basis of complete mtDNA sequencing, we have revised the classification of haplogroups A, D2, G1, M7, and I; identified six new subhaplogroups (I4, N1e, G1c, M7d, M7e, and J1b2a); and fully characterized haplogroups N1a and G1b, which were previously described only by the first hypervariable segment (HVS1) sequencing and coding-region restriction-fragment–length polymorphism analysis. Our findings indicate that the southern Siberian mtDNA pool harbors several lineages associated with the Late Upper Paleolithic and/or early Neolithic dispersals from both eastern Asia and southwestern Asia/southern Caucasus. Moreover, the phylogeography of the D2 lineages suggests that southern Siberia is likely to be a geographical source for the last postglacial maximum spread of this subhaplogroup to northern Siberia and that the expansion of the D2b branch occurred in Beringia 7,000 years ago. In general, a detailed analysis of mtDNA gene pools of northern Asians provides the additional evidence to rule out the existence of a northern Asian route for the initial human colonization of Asia.