A New aDENNDum to Genetics of Childhood Asthma

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• 作者：Marie Godar¹ ; ² ; Bart N. Lambrecht¹ ; ³ ; ⁴ ; ^{bart.lambrecht@ugent.be" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2016
• 出版时间：14 January 2016
• 年：2016
• 卷：164
• 期：1-2
• 页码：11-13
• 全文大小：666 K

文摘

Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a molecular basis for how DENND1B contributes to asthma pathogenesis.