Genetic variability of innate immunity impacts human susceptibility to fungal diseases

详细信息    查看全文

• 作者：Agostinho Carvalho ; Cristina Cunha ; Aless ; ro C. Pasqualotto ; Lucia Pitzurra ; David W. Denning ; Luigina Romani
• 关键词：Innate immunity ; Polymorphism ; Fungi ; Infection ; Susceptibility
• 刊名：International Journal of Infectious Diseases
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：14
• 期：6
• 页码：e460-e468
• 全文大小：305 K

文摘

Fungi are a major threat in immunocompromised patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop fungal diseases. The traditional view of immune suppression as a key risk factor for susceptibility to fungal infections needs to be accommodated within new conceptual advances on host immunity and its relationship to fungal disease. The critical role of the immune system emphasizes the contribution of host genetic polymorphisms to fungal disease susceptibility. This review highlights the present knowledge on innate immunity genetics that associates with susceptibility to fungal diseases.