BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin
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- 作者：Deepu Oommena ; Dennis Yiannakisb ; Awadhesh N. Jhaa ; a.jha@plymouth.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Auranofin ; BRCA1 ; Nrf2 ; DNA damage ; Ovarian cancer
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：February-March 2016
- 年：2016
- 卷：784-785
- 期：Complete
- 页码：8-15
- 全文大小：1882 K
文摘
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BRCA1 deficient cancer cells exhibit increased DNA damage upon auranofin treatment.
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Auranofin induces apoptosis in BRCA1 deficient cancer cells despite the activation of Nrf2.
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Antioxidant protects BRCA1 deficient cancer cells from auranofin.