Validation of remote dielectric sensing (ReDS™) technology for quantification of lung fluid status: Comparison to high resolution chest computed tomography in patients with and without acute heart failure

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• 作者：Offer Amir^a ; ^g ; Zaher S. Azzam^b ; ^h ; Tamar Gaspar^c ; ^h ; Suzan Faranesh-Abboud^c ; ^h ; Nizar Andria^b ; ^h ; Daniel Burkhoff^d ; Aharon Abbo^e ; William T. Abraham^f ; ^{William.Abraham@osumc.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fluid management ; Heart failure ; Diuretics ; Telemonitoring
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：221
• 期：Complete
• 页码：841-846
• 全文大小：738 K

文摘

Pulmonary congestion is a common presentation of acute decompensated heart failure (ADHF). The ability to quantify increased pulmonary parenchymal water content in chest computed tomography (CCT) is well known. However, availability and radiation limitations make it unsuitable for serial assessment of lung fluid content. The ReDS™ technology allows quantification of lung fluid content.

Objective

The objective of this work was to validate the ability of the ReDS™ technology to quantify total lung fluid when compared with CCT in ADHF and non-ADHF patients.

Methods

Following CCT, ReDS measurements were obtained from consented subjects. ReDS measurements were then compared to the CCT using lung density analysis software. CCT results were converted from Hounsfield Units to percentage units, allowing comparison with the ReDS readings. The analyses, performed on 16 ADHF and 15 non-ADHF patients, were conducted by an independent observer blinded to ReDS outcomes.

Results

The fluid content averages and standard deviations for the non-ADHF group were 28.7 ± 5.9% and 27.3 ± 6.6% and for the ADHF patients 40.7 ± 8.8% and 39.8 ± 6.8% (CCT and ReDS respectively). Intraclass correlation was found to be 0.90, 95% CI [0.8–0.95]. Regression analysis yielded a slope of 0.94 (95% confidence interval [0.77–1.12]) and intercept 3.10 (95% confidence interval of [− 3.02–9.21]). The absolute mean difference between the quantification of the two methods was 3.75 [%] with SD of 2.22 [%].

Conclusion

Current findings show high correlation between the ReDS noninvasive system and CCT in both ADHF and non-ADHF patients. Remote patient monitoring using ReDS™ based system may help in the management of patients with heart failure.