The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets

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• 作者：Alper Tunga Ö ; zdemir^a ; ^{alpertungaozdemir@gmail.com} ; ^{alpertungaozdemir@mail.ege.edu.tr} ; Rabia Bilge Ö ; zgü ; l Ö ; zdemir^b ; Cengiz Kırmaz^c ; Ayla Eker Sarıboyacı^d ; Zehra Seda Ü ; nal Halbutoğlları^e ; Ceren Ö ; zel^e ; Erdal Karaö ; z^f ; ^g
• 关键词：MSC ; Mesenchymal stem cell ; DP ; dental pulp ; CD ; cluster of differentiation ; HLA ; human leukocyte antigen ; IDO ; indoleamine-pyrrole 2 3-dioxygenase ; PGE2 ; prostaglandin E2 ; HGF ; hepatocyte growth factor ; TGF ; transforming growth factor ; Th ; T helper ; IL ; interleukin ; AF ; amniotic fluid ; P ; placental ; AM ; amniotic membrane ; BM ; bone marrow ; SHED ; stem cells from human exfoliated deciduous teeth ; UC ; umbilical cord ; AT ; adipose tissue ; PBS ; phosphate-buffered saline ; DMEM ; Dulbecco&rsquo ; s modifie
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：108-115
• 全文大小：2274 K
• 卷排序：310

文摘

hDP-MSCs significantly inhibited the proliferation of PHA-stimulated CD4+ T cells. The CD4+Tbet+ and CD4+Gata3+ T cells were decreased by the hDP-MSCs. The CD4+Stat3+ and CD4+CD25+FoxP3+ T cells were increased by the hDP-MSCs. HGF may be important to plasticity of immunosuppressive regulatory Th17 cells.