- 作者：Victor Charoenrook ; MD ; PhD1 ; 2 ; Ralph Michael ; PhD2 ; ralphm@barraquer.com" class="auth_mail" title="E-mail the corresponding author ; Maria Fideliz de la Paz ; MD ; PhD1 ; 2 ; Angela Ding ; MD1 ; Rafael I. Barraquer ; MD ; PhD1 ; 2 ; Jose Temprano ; MD ; PhD1
- 关键词：anatomical results ; complications ; functional results ; keratoprosthesis ; tibial bone
- 刊名：The Ocular Surface
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：14
- 期：4
- 页码：495-506
- 全文大小：2794 K
Methods
We reviewed 113 charts of patients who underwent tibial bone osteokeratoprothesis implantation at the Centro de Oftalmologia Barraquer. Kaplan-Meier survival curves with 95% confidence interval were calculated for functional success, defined as best corrected visual acuity (BCVA) ≥0.05 on the decimal scale, and for anatomical success, defined as retention of the keratoprosthesis lamina. Multivariate analysis was used to test the impact of clinical factors on anatomical and functional survival rates.
Results
Based on Kaplan-Meier analyses, tibial bone keratoprosthesis 5-year and 10-year anatomical survival rates were 69.5% and 53.5%, respectively. Functional survival rate at 5 years was 33% and at 10 years was 19.2%. Considering primary diagnosis, chemical burn had better anatomical and functional survival rates than autoimmune or infectious diseases. Patient age did not have a significant effect on keratoprosthesis survival rates. About 48.7% of the patients who underwent surgery had complications: keratoprosthesis extrusion, glaucoma, retinal detachment and buccal mucosa necrosis were the most frequent ones.
Conclusion
Half of the patients with tibial bone KPro had retained the keratoprosthesis after 10 years post-surgery and one-fifth of them had visual acuity of 0.05 or better at the same period. Considering that these patients have no other way to recover their vision either because they have no canine tooth or their buccal or dental conditions are not adequate for OOKP, this modified surgery is their only hope.