Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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- 作者：Josè ; Manuel Pioner1 ; jose.pioner@unisi.it" class="auth_mail" title="E-mail the corresponding author ; Alice W. Racca2 ; Jordan M. Klaiman2 ; Kai-Chun Yang3 ; Xuan Guan4 ; Lil Pabon5 ; Veronica Muskheli5 ; Rebecca Zaunbrecher2 ; Jesse Macadangdang2 ; Mark Y. Jeong6 ; David L. Mack4 ; 7 ; Martin K. Childers4 ; 7 ; Deok-Ho Kim2 ; Chiara Tesi1 ; Corrado Poggesi1 ; Charles E. Murry2 ; 3 ; 5 ; 7 ; 8 ; Michael Regnier2 ; 7 ; 8
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：6
- 期：6
- 页码：885-896
- 全文大小：2113 K
文摘
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The contractile properties of hiPSC-CM myofibrils have not been previously studied
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hiPSC-CMs cultured on nanopatterned surfaces develop elongated, aligned myofibrils
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hiPSC-CMs myofibrils have contractile properties similar to human fetal myofibrils
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hiPSC-CMs can be used to study development of genetically based cardiac diseases