CYP21A2 expression is localized in the developing distal epithelium of the human perinatal lung and is compatible with in situ production and intracrine actions of active glucocorticoids
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- 作者：Wafae Bouhaddiouia ; c ; Pierre R. Provosta ; b ; c ; Yves Tremblaya ; b ; c ; yves.tremblay@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：11-Deoxycortisol ; 21-Hydroxylase ; Deoxycorticosterone ; Glucocorticoids ; Lung development ; Mineralocorticoids ; Respiratory distress syndrome
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：12-19
- 全文大小：2056 K
文摘
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CYP21A2 mRNA and protein are present in the human developing lung.
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CYP21A2 is expressed in the distal epithelium of the human fetal lung.
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Low CYP17A1 protein levels are present in the human developing lung.
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CYP11B1 and CYP11B2 are not expressed in the tested fetal human lung samples.
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A role for CYP21A2 in intracrine glucocorticoid action is suggested.