Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity

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• 作者：Neera Tewari-Singh^a ; ^{Neera.tewari-singh@ucdenver.edu} ; Dinesh G Goswami^a ; Rama Kant^a ; Claire R Croutch^b ; Robert P Casillas^b ; David J Orlicky^c ; Rajesh Agarwal^a
• 关键词：COX-2 ; cyclooxygenase-2 ; CX ; phosgene oxime (dichloroformoxime) ; MPO ; myeloperoxidase ; TUNEL ; Terminal deoxynucleotidyl transferase (TdT) dUTP NickEnd Labeling ; TNFα ; Tumor necrosis factor α ; MAPKs ; Mitogen-activated protein kinases
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：317
• 期：Complete
• 页码：25-32
• 全文大小：1610 K
• 卷排序：317

文摘

Phosgene oxime cutaneous exposure causes skin blanching, edema and urticaria. Penetration of phosgene oxime causes dilation of vasculature in internal organs. Mast cells could play an important role in phosgene oxime-induced skin injury. Phosgene oxime could induce low blood pressure and hypoxia leading to mortality. Data is significant for developing a phosgene oxime-induced skin injury model.