- 作者：Natalia Jaworska ; Pierre Blier ; Wendy Fusee ; Verner Knott
- 关键词：Depression ; Intensity/loudness dependence of the auditory evoked potential (IDAEP/LDAEP) ; Standardized low-resolution brain electromagnetic tomography (sLORETA) ; Sex differences ; 5-Hydroxytryptamine (5-HT)
- 刊名：Clinical Neurophysiology
- 出版年：2012
- 出版时间：September, 2012
- 年：2012
- 卷：123
- 期：9
- 页码：1769-1778
- 全文大小：919 K
Objective
As major depressive disorder (MDD) is associated with altered 5-HT activity, we probed intensity-dependent auditory evoked potentials (AEPs) and loudness dependence of the AEP (LDAEP) slopes, shown pre-clinically to be inversely related to 5-HT activity, in MDD.Methods
AEPs and LDAEP slopes were measured in MDD (N = 50; 27 females) and controls (N = 43; 23 females). Correlations between scalp AEPs/LDAEPs and low-resolution electromagnetic tomography (sLORETA)-derived indices were assessed.
Results
Smaller scalp intensity-dependent N1 and N1/P2 amplitudes in MDD versus control males and longer P2 latencies in MDD versus control females were found; no LDAEP group differences existed. Females had greater scalp AEPs, steeper N1 and N1/P2 scalp LDAEPs as well as greater intensity-dependent primary auditory cortex activation during the N1 than males. Scalp LDAEPs correlated weak-moderately with sLORETA counterparts. P2 LDAEP-sLORETA correlated negatively with MADRS scores. Female P2 and N1/P2 LDAEP-sLORETA correlated negatively with HAMD-17 and MADRS scores.
Conclusions
MDD was not associated with altered LDAEPs. Impaired processing or potentiated inhibition of auditory stimuli was found in MDD males; longer processing existed in MDD females. Inverse relationships between LDAEPs and clinical scores may be related to treatment history, personality and/or MDD features.
Significance
MDD was not associated with an altered LDAEP, though subtle AEPs alterations were noted in MDD.