Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy

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• 作者：Yue Zhang^a ; ¹ ; Xiang Gao^b ; ¹ ; Shuanggang Chen^c ; Min Zhao^c ; Jing Chen^c ; Rui Liu^c ; Shengyang Cheng^c ; Mengyuan Qi^c ; Shuo Wang^c ; Wei Liu^c ; ^{weiliu0209@hebmu.edu.cn}
• 关键词：Cyclin-dependent kinase 5 ; Podocyte ; Diabetic nephropathy ; Endoplasmic reticulum stress ; Apoptosis
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：31-40
• 全文大小：1741 K
• 卷排序：31

文摘

High glucose induced endoplasmic reticulum (ER) stress in podocytes. Inhibition of ER stress attenuated podocyte apoptosis and Cdk5 expression induced by high glucose. ER stress via Cdk5 to phosphorylate MEKK1 at Ser280 in podocytes Inhibition of Cdk5 and MEKK1 decreased phosphorylation of JNK and podocyte apoptosis induced by ER stress.