Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation
详细信息 查看全文
- 作者：Chongwei Chena ; Xiaochun Weia ; Shaowei Wanga ; b ; Qiang Jiaoa ; Yang Zhanga ; b ; Guoqing Dub ; Xiaohu Wanga ; Fangyuan Weic ; Jianzhong Zhangc ; Lei Weia ; b ; lei_wei@brown.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HDAC4 ; histone deacetylase 4 ; GFP ; green fluorescent protein ; PI ; propidium iodide ; PP2A ; Ser/Thr-phosphoprotein phosphatases 2A ; OA ; okadaic acid ; Ps-HDAC4 ; phosphorylated-HDAC4 ; LK1 ; polo-like kinase 1 ; CDKN1A ; cyclin-dependent kinase inhibitor 1A
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1863
- 期：7
- 页码：1633-1642
- 全文大小：2122 K
文摘
- •
Compression induces HDAC4 nuclear relocation in chondrocytes.
- •
Compression regulates chondrocytes gene expression through HDAC4 nuclear relocation.
- •
Compression induces HDAC4 nuclear import by dephosphorylation of HDAC4 in a PP2A-dependent manner.