Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment
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- 作者：Jiao-jie Huia ; b ; 1 ; Guang-jun Xic ; 1 ; Shan-shan Liub ; Xiao-li Lib ; Lei-yu Gengb ; Gao-jun Tengd ; Bin-bin Niee ; Bao-ci Shane ; Jie Yana ; Liang Donga ; Gavin P. Reynoldsf ; Zhi-jun Zhangb ; zhijunzhang838@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author ; 88259725@qq.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Rat ; Magnetic resonance imaging ; Blood oxygen level-dependent ; Escitalopram
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：210-218
- 全文大小：1340 K
文摘
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Both CUMS and MS rat groups demonstrated depression-like behaviours and cognitive impairment, which could be modified by chronic escitalopram treatment.
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Increased BOLD activation was observed in some brain regions of MS and CUMS animals, such as the bilateral hypothalamus, limbic system, hippocampus and frontal lobe, which are parts of mood-regulating circuit.
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The MS- and CUMS-induced increases in BOLD activation were partially attenuated by chronic escitalopram treatment.