Effect of surface bilayer charges on the magnetic field around ionic channels

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• 作者：Marí ; lia Amá ; vel Gomes Soares^a ; Celia Martins Cortez^a ; ^b ; ^{ccortezs@ime.uerj.br" class="auth_mail" title="E-mail the corresponding author} ; Frederico Alan de Oliveira Cruz^a ; ^c ; Dilson Silva^a ; ^b
• 关键词：Ion channels ; Magnetic field ; Surface charge ; Biological membrane ; Finite element method
• 刊名：Physica B: Physics of Condensed Matter
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：504
• 期：Complete
• 页码：86-91
• 全文大小：697 K

文摘

In this work, we present a physic-mathematical model for representing the ion transport through membrane channels, in special Na⁺ and K⁺-channels, and discuss the influence of surface bilayer charges on the magnetic field behavior around the ionic current. The model was composed of a set of equations, including: a nonlinear differential Poisson-Boltzmann equation which usually allows to estimate the surface potentials and electric potential profile across membrane; equations for the ionic flux through channel and the ionic current density based on Armstrong's model for Na⁺ and K⁺ permeability and other Physics concepts; and a magnetic field expression derived from the classical Ampère equation. Results from computational simulations using the finite element method suggest that the ionic permeability is strongly dependent of surface bilayer charges, the current density through a K⁺-channel is very less sensible to temperature changes than the current density through a Na⁺- channel, active Na⁺-channels do not directly interfere with the K⁺-channels around, and vice-versa, since the magnetic perturbation generated by an active channel is of short-range.