Effects of a pyrrole-based, microtubule-depolymerizing compound on RAW 264.7 macrophages
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- 作者：John A. Ciemnieckia ; 1 ; john.ciemniecki@richmond.edu" class="auth_mail" title="E-mail the corresponding author ; Clarke P. Lewisa ; 2 ; clarke.lewis@richmond.edu" class="auth_mail" title="E-mail the corresponding author ; John T. Guptonb ; 3 ; jgupton@richmond.edu" class="auth_mail" title="E-mail the corresponding author ; Krista Fischer-Stengera ; kstenger@richmond.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：JG-03-14 pyrrole compound ; RAW264.7 macrophages ; Inflammation ; NF-κB ; TNF-α ; Nitric oxide
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 February 2016
- 年：2016
- 卷：246
- 期：Complete
- 页码：63-68
- 全文大小：986 K
文摘
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JG-03-14 is a microtubule-depolymerizing compound with antitumor activity.
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JG-03-14 decreases pro-inflammatory molecules produced by activated macrophages.
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JG-03-14 may attenuate the pro-inflammatory NFκB signaling pathway.