Maternal separation stress reduced both LTP and LTD at the thalamic input to the lateral amygdala.
Maternal separation stress impaired LTP and enhanced LTD at the cortical input to the lateral amygdala.
Treatment with imipramine restored the extent of the synaptic modification range at the thalamic input.
Treatment with imipramine restored the potential for LTD, but not for LTD, at the cortical input.
Imipramine-mediated restoration of synaptic plasticity will have consequences for amygdala-dependent learning.