Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices
Oxygen-glucose deprivation (OGD) mimicks many features of brain ischemia. OGD evokes differential responses in the Substantia Nigra in brain slice. During OGD, anoxic depolarization (AD) occurred only in the SN pars reticulata (SNr). The absence of AD in the SN pars compacta (SNc) reflects resilience of its dopaminergic neurons. The differing ischemic responses may explain the mechanisms underlying acute-onset motor disorders.