Influence of SKF38393 on changes of gene profile in rat prefrontal cortex during chronic paradoxical sleep deprivation
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- 作者：Xiaosa Wena ; b ; 1 ; Xinmin Chena ; 1 ; Si Chena ; Yue Tanc ; Fei Ronga ; Jiangbo Zhua ; jiangbozhu@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Wenling Maa ; wenlingma@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chronic paradoxical sleep deprivation ; Prefrontal cortex ; D1 receptor ; SKF38393 ; Signaling pathway ; Gene chip
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：60-66
- 全文大小：854 K
文摘
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Gene chip was used to screened the expression of transcripts in the PFC of CSD rats.
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59 transcripts were significantly changed after 21 days-CSD.
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2 transcripts were specifically reversed by D1R agonist SKF38393.
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D1R agonist might improve neural dysfunction of PFC through Ca2+ and MAPK pathway.