Dynamic measurements of total hepatic blood flow with Phase Contrast MRI

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• 作者：Thierry Yzet ; Roger Bouzerar ; Olivier Baledent ; Cedric Renard ; Didier Mbayo Lumbala ; Eric Nguyen-Khac ; Jean-Marc Regimbeau ; H. Deramond ; Marc-Etienne Meyer
• 关键词：PC-MRI ; Hepatic hemodynamics ; Hepatic artery ; Portal vein ; Total hepatic flow
• 刊名：European Journal of Radiology
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：73
• 期：1
• 页码：119-124
• 全文大小：720 K

文摘

<h4 class=""h4"">Background/Aimsh3>To measure total hepatic blood flow including portal and proper hepatic artery flows as well as the temporal evolution of the vessel's section during a cardiac cycle.<h4 class=""h4"">Methodsh3>

Twenty healthy subjects, with a mean age of 26 years, were explored. Magnetic resonance imaging blood flow measurements were carried out in the portal vein and the proper hepatic artery. MR studies were performed using a 1.5T imager (General Electric Medical Systems). Gradient-echo 2D Fast Cine Phase Contrast sequences were used with both cardiac and respiratory gatings. Data analysis was performed using a semi-automatic software built in our laboratory.<h4 class=""h4"">Resultsh3>

The total hepatic flow rate measured was 1.35 ± 0.18 L/min or 19.7 ± 4.6 mL/(min kg). The proper hepatic artery provided 19.1 % of the total hepatic blood flow entering the liver. Those measurements were in agreement with earlier studies using direct measurements.

Mean and maximum velocities were also assessed and a discrepancy between our values and the literature's Doppler data was found.

Measurements of the portal vein area have shown a mean variation, defined as a “pulsatility” index of 18 % over a cardiac cycle.<h4 class=""h4"">Conclusionsh3>

We report here proper hepatic artery blood flow rate measurements using MRI. Associated with portal flow measurements, we have shown the feasibility of total hepatic flowmetry using a non-invasive and harmless technique.