HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry

详细信息    查看全文

• 作者：Janette Kwok^a ; ^{kwoksy@ha.org.hk} ; Mengbiao Guo^b ; Wanling Yang^b ; C.K. Lee^c ; N.K. Chan^c ; Jenny Ho^a ; W.H. Tang^a ; Y.S. Chan^a ; Derek Middleton^d ; L.W. Lu^e ; Godfrey C.F. Chan^b
• 关键词：HLA ; Gene frequency ; Haplotype frequency ; Cord blood ; Hong Kong ; Chinese ; Registry
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：77
• 期：12
• 页码：1109-1110
• 全文大小：287 K
• 卷排序：77

文摘

HLA-A, -B and -DRB1 gene and haplotype frequencies have been calculated from 3892 southern Chinese unrelated cord blood units in a Hong Kong Cord Blood Registry. This is the first large-scale paper to report the distribution of A-B-DRB1 alleles in Hong Kong Chinese Cord Blood Units. This information is important for estimating the optimal and economically cost-effective donor size and likelihood of obtaining appropriately matched cord blood units for Chinese patients awaiting haematopoietic stem cell transplantation. The data are available in the Allele Frequencies Net Database under the population name ‘‘Hong Kong Chinese Cord Blood Registry’’ and the identifier (AFND003358).