Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
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- 作者：Derek K. Smith1 ; 2 ; Jianjing Yang1 ; 2 ; Meng-Lu Liu1 ; 2 ; Chun-Li Zhang1 ; 2 ; chun-li.zhang@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NEUROG2 ; SOX4 ; SWI/SNF ; CREB1 ; small molecules ; reprogramming ; transdifferentiation ; ATAC-seq ; ChIP-seq ; RNA-seq
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：7
- 期：5
- 页码：955-969
- 全文大小：2694 K
文摘
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NEUROG2 acts as a pioneer factor to drive neuronal reprogramming
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ATAC-, ChIP-, and RNA-seq profiling reveals genome-wide mechanisms for reprogramming
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SOX4 is a critical mediator of chromatin remodeling during reprogramming
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SOX4 or FK228 can enhance adult human glioblastoma and skin fibroblast reprogramming