Study on synthesis of ferrocene-based boronic acid derivatives and their saccharides sensing properties

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• 作者：Muhammad Saleem ; Haojie Yu ; ^{hjyu@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Li Wang ; ^{opl_wl@dial.zju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zain-ul-Abdin ; Hamad Khalid ; Muhammad Akram ; Nasir M. Abbasi ; Yongsheng Chen
• 关键词：Ferrocene ; Boronic acid ; Saccharide ; Sensing
• 刊名：Journal of Electroanalytical Chemistry
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：763
• 期：Complete
• 页码：71-78
• 全文大小：1485 K

文摘

In this article ferrocene monoamino phenyl boronic acid (FcMAPBA) and ferrocene diamino phenyl boronic acid (FcDAPBA) were synthesized and characterized by ¹H NMR and FTIR. Particular emphasis is given to cis-diol and saccharide binding affinities with ferrocene amino phenyl boronic acid (FcAPBAs) which was investigated by ¹H NMR and CV (using sorbitol). Free and bound forms of derivatives were depicted from disappearance of boronic acid hydroxyls signal in ¹H NMR spectra. The presence of two discrete peaks in the CV curves is in agreement with ¹H NMR spectra, as the indication of cis-diol binding with saccharides. It was also proposed that this approach using potential shift difference in CV curves can be applied for surface confined glycated molecules detection.