Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells
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- 作者：Xiaohui Yina ; b ; Yang Lib ; Jingwen Lia ; Peng Lic ; Yinan Liub ; Jinhua Wenb ; jhwen@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qingxian Luana ; kqluanqx@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Induced pluripotent stem cells ; Human gingival fibroblasts ; Enamel matrix derivative ; Growth/differentiation factor-5 ; Differentiation ; Periodontal regeneration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：6 May 2016
- 年：2016
- 卷：473
- 期：3
- 页码：726-732
- 全文大小：2171 K
文摘
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Integration-free iPSCs are successfully generated from hGFs via an episomal approach.
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EMD promotes differentiation of the hGFs-derived iPSCs toward periodontal cells.
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GDF-5 promotes differentiation of the hGFs-derived iPSCs toward periodontal cells.
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hGFs-derived iPSCs could be a promising cell source for periodontal regeneration.