Synthesis and evaluation of antifungal activity of C₂₁-steroidal derivatives

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• 作者：Lie-Jun Huang^a ; ^b ; Bin Wang^b ; Jian-Xin Zhang^b ; Chun-Mao Yuan^b ; Wei Gu^b ; Shu-zhen Mu^b ; Xiao-Jiang Hao^b ; ^{haoxj@mail.kib.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Caudatin ; Qingyangshengenin ; C21-steroidal derivatives ; Antifungal activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 April 2016
• 年：2016
• 卷：26
• 期：8
• 页码：2040-2043
• 全文大小：613 K

文摘

The antifungal activities of eleven C₂₁-steroidal compounds isolated from Cynanchum wilfordii, together with thirty-six derivatives of caudatin and qingyangshengenin were evaluated on Sclerotinia sclerotiorum and other five fungal strains by the mycelium growth rate method. Four derivatives 1k, 1y, 10d, and 10j exhibited much stronger inhibitions on growth of S. sclerotiorum with IC₅₀ values of 0.0084, 0.0049, 0.0053, and 0.0034 μM, respectively.