Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents

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• 作者：Abdulrhman Alsayari^b ; Lucas Kopel^a ; Mahmoud Salama Ahmed^c ; Adam Pay^a ; Taylor Carlson^a ; Fathi T. Halaweish^a ; ^{fathi.halaweish@sdstate.edu}
• 关键词：Breast cancer ; Estrone ; Estrogenic/anti-estrogenic activity ; Breast cancer (MCF-7) cell lines
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：32-40
• 全文大小：2171 K
• 卷排序：118

文摘

Series of estrone analogs were synthesized. Cell proliferation, cytotoxicity, and estrogenic/anti-estrogenic activities were evaluated. LA-7 alcohol derivative exhibited selective anti-estrogenic activity towards ER-α at 5.49 μM.