Therapeutic role of nitric oxide as emerging molecule

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• 作者：Sahil Kumar^a ; ^b ; ^{sahil.mehta187@gmail.com} ; Rajesh K. Singh^c ; ^{rksingh244@gmail.com} ; T.R. Bhardwaj^a ; ^b
• 关键词：Nitric Oxide(NO) ; NO-donors ; Antimalarial ; Antihypertensive ; Non steroidal anti-inflammatory Drugs(NSAIDs)
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：182-201
• 全文大小：2641 K
• 卷排序：85

文摘

NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune system, gastroprotection, as antioxidant and reported to be a free radical scavenger.Intensive research on the biological functions of NO and other reactive nitrogen oxide species demands exogenous sources of NO donors as research tools and pharmaceuticals. Since the mid-1980s, the development of new NO donors has offered several advantages over theprevious NO donors, such as spontaneous release of NO, donation of NO under controlled rates, and even the targeting of NO to certain tissues. Nitric oxide releasing derivatives of conventional NSAIDs have been synthesized not only to avoid gastrotoxicity, but also for making them fit for topical delivery, targeting them to brain and increase their analgesic and anti-inflammatory activity. “Hybrid nitrates” have vital role in different like NSAIDs, Anti-platelet, Antileukemic, Glaucoma, Antihypertensive, Antimalarial etc.