Synthesis of type 2 Lewis antigens via novel regioselective glycosylation of an orthogonally protected lactosamine diol derivative
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- 作者：Yuji Yamazaki ; Kyohei Sezukuri ; Junko Takada ; Hiroaki Obata ; Shunsaku Kimura ; Masashi Ohmae ; ohmae@peptide.polym.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 2 Lewis antigens ; Sulfated Lewis x ; Lewis y ; Regioselective glycosylation ; The Heyns rearrangement
- 刊名：Carbohydrate Research
- 出版年：2016
- 出版时间：3 March 2016
- 年：2016
- 卷：422
- 期：Complete
- 页码：34-44
- 全文大小：471 K
文摘
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A facile and rapid synthesis of type 2 Lewis antigens is demonstrated.
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A newly designed diol acceptor shows unique reactivity of 3-OH > 2′-OH.
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On-demand synthesis of Lex and Ley is achieved with this new diol acceptor.
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Synchronous synthesis of Lex and Ley is performed in this study for the first time.