Penicillosides A and B: new cerebrosides from the marine-derived fungus Penicillium species

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• 作者：Samar S.A. Murshid^a ; Jihan M. Badr^a ; ^b ; Diaa T.A. Youssef^a ; ^{dyoussef@kau.edu.sa" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Didemnum ; Penicillum ; Cerebrosides ; Penicillosides ; Antimicrobial activity ; HeLa cells
• 刊名：Revista Brasileira de Farmacognosia
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：26
• 期：1
• 页码：29-33
• 全文大小：545 K

文摘

In the course of our ongoing effort to identify bioactive compounds from marine-derived fungi, the marine fungus, Penicillium species was isolated from the Red Sea tunicate, Didemnum species. Two new cerebrosides, penicillosides A and B were isolated from the marine-derived fungus, Penicillium species using different chromatographic methods. Their structures were established by different spectroscopic data including 1D (¹H NMR and ¹³C NMR) and 2D NMR (COSY, HSQC, and HMBC) studies as well as high-resolution mass spectral data. Penicilloside A displayed antifungal activity against Candida albicans while penicilloside B illustrated antibacterial activities against Staphylococcus aureus and Escherichia coli in the agar diffusion assay. Additionally, both compounds showed weak activity against HeLa cells.