Amniotic fluid glycosaminoglycans in the prenatal diagnosis of mucopolysaccharidoses - A useful biomarker
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- 作者：Radha Rama Devi Akellaa ; radharamadevi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Srilatha Kadalib
- 关键词：LSD ; lysosomal storage diseases ; MPS ; mucopolysaccharidoses ; PND ; prenatal diagnosis ; GAG ; glycosaminoglycan ; AMF ; amniotic fluid ; 2-DE ; 2-dimensional electrophoresis ; CS ; chondroitin sulphate ; HA ; hyaluronic acid ; DS ; dermatan sulphate ; IDS ; iduronate-2-sulfatase ; KS ; keratin sulphate
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：460
- 期：Complete
- 页码：63-66
- 全文大小：358 K
文摘
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Glycosaminoglycans of amniotic fluid consist of hyluronic acid and chondroitin sulphate.
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High concentrations of glycoproteins are excreted in fetus affected with MPS.
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The study established normative data for MPS at 16-22 weeks gestation.
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It is a useful screening test in advanced pregnancies for a quick recognition of MPS.