Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or combined, for the treatment of hot flashes in menopausal women: a randomized, double-blind, placebo-controlled study
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- 作者：James Liu ; Adam Allgood ; Leonard R. Derogatis ; Stephen Swanson ; Michael O’ ; Mahony ; Bertr ; Nedoss ; Herbert Soper ; Edward Zbella ; Svetlana Vladimirovna Prokofieva ; Lisa Zipfel ; Chun-Yuan Guo
- 关键词：Postmenopausal women ; vasomotor symptoms ; hot flashes ; hormone replacement therapy ; esterified estrogens (EE) ; methyltestosterone (MT) ; lowest effective dose
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：95
- 期：1
- 页码：366-368
- 全文大小：196 K
文摘
This study evaluated safety and efficacy of esterified estrogens and methyltestosterone administered alone or in combination for the treatment of hot flashes in menopausal women. The 0.30-mg esterified estrogens and 0.30-mg methyltestosterone combination was the lowest effective dose, and our results are consistent with the known safety profile of estrogen and androgen combination products.