Genetic deletion of galectin-3 enhances neuroinflammation, affects microglial activation and contributes to sub-chronic injury in experimental neonatal focal stroke

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• 作者：Sophorn Chip ; David Ferná ; ndez-Ló ; pez ; Fan Li ; Joel Faustino ; Nikita Derugin ; Zinaida S. Vexler ; ^{Zena.Vexler@ucsf.edu}
• 关键词：Microglia ; Middle cerebral artery occlusion ; Neonate ; Cytokine ; AlphaV beta3 integrin
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：270-281
• 全文大小：3716 K
• 卷排序：60

文摘

Galectin-3 (Gal3) protects from early injury after neonatal stroke. Gal3 is induced in activated microglia/macrophages. Lack of Gal3 attenuates microglial activation. Lack of Gal3 alters integrin expression and cell-extracellular matrix interactions.