High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders
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- 作者：Daniel F. Preisig ; Luka Kulic ; Maik Krü ; ger ; Fabian Wirth ; Jordan McAfoose ; Claudia Spä ; ni ; Pascal Gantenbein ; Rebecca Derungs ; Roger M. Nitsch ; Tobias Welt ; tobias.welt@bli.uzh.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Video gait analysis ; Locomotion ; Amyotrophic lateral sclerosis ; Huntington's disease ; Cerebellar ataxia ; Neurodegeneration
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：340-353
- 全文大小：3935 K
文摘
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Full body high-speed video gait analysis increases specificity in motor testing.
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Comprehensive locomotor profiles are generated by a custom-built algorithm.
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Gait patterns of ALS, Huntington and cerebellar ataxia models differ substantially.
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Early and specific gait changes were found for each of the three models analyzed.
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Analysis of locomotor function is essential for the development of new therapies.