Gender differences of peripheral plasma and liver metabolic profiling in APP/PS1 transgenic AD mice
详细信息 查看全文
- 作者：Junfang Wua ; Bin Fub ; Hehua Leia ; Huiru Tanga ; c ; huiru_tang@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yulan Wanga ; d ; yulan.wang@wipm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; AMP ; adenosine monophosphate ; APP ; amyloid precursor protein ; D5D ; delta-5-desaturase ; D6D ; delta-6-desaturase ; FADS ; fatty acid desaturase genes ; FT ; female transgenic group ; GC-MS ; gas chromatography-mass spectrometry ; MT ; male transgenic group ; PCA ; principal component analysis ; PLS-DA ; partial least squares discriminant analysis ; PUFA ; polyunsaturated fatty acids ; SCD ; stearoyl-CoA-desaturase ; UMP ; uridine monophosphate ; UDP ; uridine diphosphate
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：22 September 2016
- 年：2016
- 卷：332
- 期：Complete
- 页码：160-169
- 全文大小：1123 K
文摘
- •
Peripheral plasma and liver are involved in Alzheimer’s disease mice model.
- •
Female AD mice show more intensive metabolic responses than male ones.
- •
Female AD mice exhibit higher activity of D6D and suppressed activity of D5D.
- •
Male AD mice show inhibited stearoyl-CoA-desaturase activity.