- 作者：Llu¨ªs Masana ; Manuel Lagares ; Xavier Pint¨® ; Le ; ro Reinares ; Manuel Z¨²?iga ; Olivier Descamps ; Emanuele Bosi ; Fran?ois Andr¨¨ Allaert ; John Chapman ; Erik Bruckert ; en representaci¨®n del Grupo RECIPE de Espa?a
- 关键词：Fitosteroles ; Hipercolesterolemia ; Estilo de vida ; Dieta ; Leche fermentada
- 刊名：Cl¡§anica e Investigaci¡§?n en Arteriosclerosis
- 出版年：2012
- 出版时间：July-August, 2012
- 年：2012
- 卷：24
- 期：4
- 页码：173-180
- 全文大小：304 K
Introduction
RECIPE study was designed to assess the impact of dietary supplementation with fermented milk enriched with plant sterols (FMPS) on the nutritional behavior, lifestyle and the joint therapeutic responsibility of hypercholesterolemic patients.
Methods
Observational, prospective, multicenter, international study, was conducted to assess dietary habits and other lifestyle components in hypercholesterolemic patients in whom the general practitioner indicated FMPS supplementation. Nutritional, lifestyle and clinical data were collected at the initial visit and after a 4 months follow-up. The biochemical and anthropometric data were retrieved from medical records obtained at baseline and 4 months.
Results
We report the results of Spain. Two hundred and one physicians who provided valid data of 1044 patients participated. The addition of FMPS was associated with improved overall nutritional index, being adequate initially in 28.2 % of patients, and increasing up to 75.2 % at the end of the study (P < .001). This nutritional change was associated with an improvement in the lipid profile and anthropometric data. Patients more adherent to therapy generally achieved a better result in all parameters compared to non-compliant ones.
Conclusions
The addition of FMPS to a diet designed to reduce the LDL enhances the patient's attitude regarding changes in lifestyle, leading to better overall control of dyslipidemia and anthropometric improvement.