- 作者：Benjamin Dallaudi猫re ; Marta Lempicki ; Lionel Pesquer ; Liliane Louedec ; Pierre Marie Preux ; Philippe Meyer ; Agathe Hess ; Marie H猫l猫ne Moreau Durieux ; Vincent Hummel ; Ahmed Larbi ; Lydia Deschamps ; Yohan Benayoun ; Clement Journe ; Anne Perozziello ; Elisabeth Schouman-Claeys ; Jean Baptiste Michel ; Jean Michel Serfaty
- 关键词：Tendon ; Anti-angiogenic ; Tendinosis ; Rat ; US
- 刊名：European Journal of Radiology
- 出版年：December, 2013
- 年：2013
- 卷：82
- 期：12
- 页码：e823-e828
- 全文大小：1613 K
Purpose
Tendinopathy shows early disorganized collagen fibers with neo-angiogenesis on histology. Peri-tendinous injection of corticosteroid is the commonly accepted strategy despite the abscence of inflammation in tendinosis. The aim of our study was to assess the potential of intratendinous injection of an anti-angiogenic drug (bevacizumab, AA) to treat tendinopathy in a murine model of patellar and Achilles tendinopathy, and to evaluate its local toxicity.Materials and method
Forty rats (160 patellar and Achilles tendons) were used for this study. We induced tendinosis (T+) in 80 tendons by injecting under ultrasonography (US) guidance Collagenase 1庐 (day 0 = D0, patellar = 40 and Achilles = 40). Clinical examination and tendon US were performed at D3, immediately followed by either AA (AAT+, n = 40) or physiological serum (PST+, n = 40, control) US-guided intratendinous injection. Follow-up at D6 and D13 using clinical, US and histology, and comparison between the 2 groups were performed. To study AA toxicity we compared the 80 remaining normal tendons (T鈭? after injecting AA in 40 (AAT鈭?.
Results
All AAT+ showed a better joint mobilization compared to PST+ at D6 (p = 0.004) with thinner US tendon diameters (p < 0.004), and less disorganized collagen fibers and neovessels on histology (p < 0.05). There was no difference at D13 regarding clinical status, US tendon diameter and histology (p > 0.05). Comparison between AAT鈭?and T鈭?showed no AA toxicity on tendon (p = 0.18).
Conclusion
Our study suggests that high dose mono-injection of AA in tendinosis, early after the beginning of the disease, accelerates tendon's healing, with no local toxicity.