Evaluation of the impact of genetic linkage in forensic identity and relationship testing for expanded DNA marker sets

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• 作者：Andreas O. Tillmar^a ; ^b ; ^{andreas.tillmar@rmv.se} ; Chris Phillips^c
• 关键词：Biostatistics ; Random match calculations ; Relationship testing ; Linkage ; Linkage disequilibrium ; Simulation ; CODIS loci
• 刊名：Forensic Science International: Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：Complete
• 页码：58-65
• 全文大小：1276 K
• 卷排序：26

文摘

A biostatistical tool for analyzing the overall effect of linkage on likelihood calculations in various forensic genetic case scenarios is presented. The tool is provided as a command script via the open-source platform R and is prepared with reference data for over 40 STRs and 140 SNPs. The tool can be used during marker selection and the design of new marker panels or applied to existing marker sets to examine the effect of linkage on a case-by-case basis. Studies of existing forensic marker panels show the impact of linkage is generally small, but may be more considerable in individual cases.