Development of diabetes-induced acidosis in the rat retina
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- 作者：Andrey V. Dmitrieva ; andrey.dmitriev@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Desmond Hendersona ; d-henderson@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Robert A. Linsenmeiera ; b ; c ; r-linsenmeier@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：pH ; Acidosis ; Diabetes ; Streptozotocin ; Rat ; Ion-selective microelectrodes ; Retina
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：149
- 期：Complete
- 页码：16-25
- 全文大小：1610 K
文摘
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We hypothesized that diabetic retinae would be acidic due to increased glycolysis.
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We measured [H+]o in retinae of control and diabetic rats with H+ microelectrodes.
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In controls, [H+]o in the outer nuclear layer is about 30 nM higher than in blood.
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Retinae were more acidic from 1 to 3 months of diabetes, but not before or after.
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[H+]o was more variable in diabetic retinae, both within and between animals.